Letrozole is used frequently as an infertility treatment. It is a recent addition to the drugs that are currently used for fertility treatment. This medication is a helpful aid to induce an egg to develop and be released in women who are not ovulating naturally; this is known as ovulation induction. Fertility drugs can also be utilized to increase the probability of pregnancy in women who are already ovulating.
Letrozole has also been shown to improve outcome in cycles combining injectable FSH with oral ovulation induction. Recent studies report that the combination of letrozole and FSH enhances follicular recruitment while reducing the amount of FSH needed for optimal stimulation, thus reducing the cost of the cycle. This method has also been useful in patients who previously responded poorly to superovulation treatment protocols.